Liver-specific loss of lipin-1-mediated phosphatidic acid phosphatase activity does not mitigate intrahepatic TG accumulation in mice
GG Schweitzer, Z Chen, C Gan, KS McCommis… - Journal of lipid …, 2015 - ASBMB
Lipin proteins (lipin 1, 2, and 3) regulate glycerolipid homeostasis by acting as phosphatidic
acid phosphohydrolase (PAP) enzymes in the TG synthesis pathway and by regulating DNA-
bound transcription factors to control gene transcription. Hepatic PAP activity could
contribute to hepatic fat accumulation in response to physiological and pathophysiological
stimuli. To examine the role of lipin 1 in regulating hepatic lipid metabolism, we generated
mice that are deficient in lipin-1-encoded PAP activity in a liver-specific manner (Alb …
acid phosphohydrolase (PAP) enzymes in the TG synthesis pathway and by regulating DNA-
bound transcription factors to control gene transcription. Hepatic PAP activity could
contribute to hepatic fat accumulation in response to physiological and pathophysiological
stimuli. To examine the role of lipin 1 in regulating hepatic lipid metabolism, we generated
mice that are deficient in lipin-1-encoded PAP activity in a liver-specific manner (Alb …
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