The nature of the in vivo cellular events underlying thrombus formation mediated by platelet
activation remains unclear because of the absence of a modality for analysis. Lymphocyte
adaptor protein (Lnk; also known as Sh2b3) is an adaptor protein that inhibits
thrombopoietin-mediated signaling, and as a result, megakaryocyte and platelet counts are
elevated in Lnk–/–mice. Here we describe an unanticipated role for Lnk in stabilizing
thrombus formation and clarify the activities of Lnk in platelets transduced through integrin …

Lnk/Sh2b3 regulates integrin αIIbβ3 outside-in signaling in mouse platelets leading to
stabilization of developine thrombus in vivo. | CiNii Research … Lnk/Sh2b3 regulates
integrin αIIbβ3 outside-in signaling in mouse platelets leading to stabilization of developine
thrombus in vivo. … タイトル Lnk/Sh2b3 regulates integrin αIIbβ3 outside-in signaling in
mouse platelets leading to stabilization of developine thrombus in vivo. …