Long term administration of some antipsychotic drugs increases body weight and feeding in rats. Are D2 dopamine receptors involved?
Long term administration of the antipsychotic drugs thioridazine, trifluoperazine, haloperidol,
and sulpiride increased body weight in rats. This effect was found to be sex dependent, that
is, while female rats were prone to gain weight, male rats did not. Chlorpromazine and
fluphenazine decreased body weight in male rats but did not affect females. The mechanism
of body weight gain was investigated with sulpiride. A linear relationship between dose of
sulpiride and body weight gain was found. Also, sulpiride increased caloric intake, and both …
and sulpiride increased body weight in rats. This effect was found to be sex dependent, that
is, while female rats were prone to gain weight, male rats did not. Chlorpromazine and
fluphenazine decreased body weight in male rats but did not affect females. The mechanism
of body weight gain was investigated with sulpiride. A linear relationship between dose of
sulpiride and body weight gain was found. Also, sulpiride increased caloric intake, and both …
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