… between genetic variants and functional elements of the genome is needed to advance our
understanding of phenotypic diversity and characterize how genetic variation can perturb cell …

… genes are regulated by dozens, possibly hundreds, of distal regulatory elements found in …
The extreme distances between regulatory elements and their target genes open a series of …

… hundred base pairs located in thousands of base pairs of … of the identified variant was shown
to confer a 2.1–5.7 times … including transcriptional repression, epigenetic regulation, and X-…

… disruption of its long-range regulation. Interestingly, enhancers located beyond the gene-distal …
In addition, the locus is subject to epigenetic regulation through the activities of Polycomb …

… than are possible via the accumulation of genetic variation. Here, we review how molecular
… ), numerous studies have found evidence for epigenetic regulation of GR. Among the most …

… of long-range gene regulation have been obtained. Gene regulatory elements are found to
… genomic distances, sometimes up to hundreds of kilobases, to exert control over their target …

… that UMLILO, an IPL located upstream of IL8, is essential for training the IL8 gene (107). Non…
caused by genetic variants creates a scaffold upon which age-induced epigenetic changes …

… histone modifications, regulating the expression of thousands of genes. … Genetic and
molecular analyses have demonstrated that the vernalization response is based on an epigenetic …

… thousands of phenotype-associated DNA sequence variants for … -associated genetic variants
may largely confer their impacts … Like ZFP57, CTCF's insulation or regulation of long-range …