Long-term estrogen deprivation leads to elevation of Dickkopf-1 and dysregulation of Wnt/β-Catenin signaling in hippocampal CA1 neurons
Surgically menopausal women incur a 2-to 5-fold increased risk for dementia and mortality
from neurological diseases, but the mechanisms underlying these increased risks remain
unclear. Previously, we demonstrated that after global cerebral ischemia (GCI), 17β-
estradiol (E2 or estrogen) suppresses hippocampal elevation of the Wnt antagonist Dickkopf-
1 (Dkk1), a neurodegenerative factor. We, thus, hypothesized that prolonged loss of E2 may
lead to dysregulation of neural Dkk1 and Wnt/β-Catenin signaling, which could contribute to …
from neurological diseases, but the mechanisms underlying these increased risks remain
unclear. Previously, we demonstrated that after global cerebral ischemia (GCI), 17β-
estradiol (E2 or estrogen) suppresses hippocampal elevation of the Wnt antagonist Dickkopf-
1 (Dkk1), a neurodegenerative factor. We, thus, hypothesized that prolonged loss of E2 may
lead to dysregulation of neural Dkk1 and Wnt/β-Catenin signaling, which could contribute to …