Longitudinal investigation of the relationship between breast milk leptin levels and growth in breast-fed infants
Journal of Pediatric Endocrinology and Metabolism, 2005•degruyter.com
Background: It has been shown that leptin is present in breast milk and human mammary
epithelial cells are able to synthesize leptin. It has been suggested that leptin in human milk
might be involved in the regulation of postnatal nutrition and growth. Aims: To investigate
whether there is a relation-ship between leptin levels in human milk and weight gain in the
postnatal period and to compare variations of milk-borne maternal leptin concentrations for
small for gestational age (SGA), large for gestational age (LGA) and appropriate for …
epithelial cells are able to synthesize leptin. It has been suggested that leptin in human milk
might be involved in the regulation of postnatal nutrition and growth. Aims: To investigate
whether there is a relation-ship between leptin levels in human milk and weight gain in the
postnatal period and to compare variations of milk-borne maternal leptin concentrations for
small for gestational age (SGA), large for gestational age (LGA) and appropriate for …
Abstract
Background: It has been shown that leptin is present in breast milk and human mammary epithelial cells are able to synthesize leptin. It has been suggested that leptin in human milk might be involved in the regulation of postnatal nutrition and growth.
Aims: To investigate whether there is a relation-ship between leptin levels in human milk and weight gain in the postnatal period and to compare variations of milk-borne maternal leptin concentrations for small for gestational age (SGA), large for gestational age (LGA) and appropriate for gestational age (AGA) infants.
Infants and Methods: Forty-seven healthy lacta-ting women aged from 17-38 years and their infants were included in the study. The infants were separated into three groups according to birth weight as SGA (η= II), LGA (n= 14) and AGA (η= 22). All infants were fed with breast milk during the study period. Anthropometric measurements were performed on the 15th day of life and at 1, 2, and 3 months of age, and the body mass index (BMI) of the infants' mothers was calculated. Breast milk leptin levels were analyzed by radioimmunoassay.
Results: Breast milk leptin levels were found reduced in the SGA group and increased in the LGA group compared to the AGA group at 15 days of life (13.4±2.2, 28.5±4.4 and 18.4±2
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