[HTML][HTML] Longitudinal study of DNA methylation and epigenetic clocks prior to and following test-confirmed COVID-19 and mRNA vaccination
APS Pang, AT Higgins-Chen, F Comite, I Raica… - Frontiers in …, 2022 - frontiersin.org
The host epigenetic landscape rapidly changes during SARS-CoV-2 infection, and evidence
suggest that severe COVID-19 is associated with durable scars to the epigenome.
Specifically, aberrant DNA methylation changes in immune cells and alterations to
epigenetic clocks in blood relate to severe COVID-19. However, a longitudinal assessment
of DNA methylation states and epigenetic clocks in blood from healthy individuals prior to
and following test-confirmed non-hospitalized COVID-19 has not been performed. Moreover …
suggest that severe COVID-19 is associated with durable scars to the epigenome.
Specifically, aberrant DNA methylation changes in immune cells and alterations to
epigenetic clocks in blood relate to severe COVID-19. However, a longitudinal assessment
of DNA methylation states and epigenetic clocks in blood from healthy individuals prior to
and following test-confirmed non-hospitalized COVID-19 has not been performed. Moreover …
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