Longitudinal urinary metabolomic profiling reveals metabolites for asthma development in early childhood

CY Chiu, G Lin, ML Cheng, MH Chiang… - Pediatric Allergy and …, 2018 - Wiley Online Library
Background Several metabolites and altered metabolic pathways have been reported to be
associated with asthma. However, longitudinal analysis of the dynamics of metabolites
contributing to the development of asthma has not yet been fully clarified. Methods We
sought to identify the metabolic mechanisms underlying asthma development in early
childhood. Thirty children with asthma and paired healthy controls from a prospective birth
cohort were enrolled. Time series analysis of urinary metabolites collected at ages 1, 2, 3 …

Longitudinal urinary metabolomic profiling reveals metabolites for asthma development in early childhood.

CCY Chiu ChihYung, LGG Lin GiGin… - 2018 - cabidigitallibrary.org
Background: Several metabolites and altered metabolic pathways have been reported to be
associated with asthma. However, longitudinal analysis of the dynamics of metabolites
contributing to the development of asthma has not yet been fully clarified. Methods: We
sought to identify the metabolic mechanisms underlying asthma development in early
childhood. Thirty children with asthma and paired healthy controls from a prospective birth
cohort were enrolled. Time series analysis of urinary metabolites collected at ages 1, 2, 3 …
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