Hepatoblastoma (HBL), the most common childhood liver cancer is cured with surgical
resection after chemotherapy or with liver transplantation if local invasion and multifocality
preclude resection. However, variable survival rates of 60–80% and debilitating
chemotherapy sequelae argue for more informed treatment selection, which is not possible
by grading the Wnt-β-catenin over activity present in most HBL tumors. A hypothesis-
generating whole transcriptome analysis shows that HBL tumors removed at transplantation …