Mutations in hepatocyte nuclear factor 1α (HNF-1 α) lead to maturity-onset diabetes of the
young type 3 as a result of impaired insulin secretory response in pancreatic β-cells. The
expression of 50 genes essential for normal β-cell function was studied to better define the
molecular mechanism underlying the insulin secretion defect in Hnf-1 α−/− mice. We found
decreased steady-state mRNA levels of genes encoding glucose transporter 2 (Glut2),
neutral and basic amino acid transporter, liver pyruvate kinase (L-Pk), and insulin in Hnf …

Loss of HNF-1alpha function in mice leads to abnormal expression of genes involved in
pancreatic islet development and metabolism | CiNii Research … Loss of HNF-1alpha
function in mice leads to abnormal expression of genes involved in pancreatic islet
development and metabolism …