Background IgG antinuclear antibodies (ANAs) are a feature of several autoimmune
diseases. These antibodies arise through defects in central or peripheral tolerance
checkpoints. The specific checkpoints breached in patients with autoimmune disease are
not fully understood. Objectives We sought to study whether autoreactive plasma cells in
lupus models and patients with systemic lupus erythematosus (SLE) arise as a
consequence of defective antigen-specific selection or a global enhancement of IgG plasma …