… The focus of the present review is on the prerequisites for cardioprotection in aged hearts,
eg the cardioprotective stimulus, the duration of ischaemia/reperfusion, and finally the …

… effector GSK3β, and ERK1/2 was not activated by anesthetic postconditioning, which
may be associated with the loss of cardioprotection in the aged rat heart. Therefore, the …

… The loss of cardioprotection with ageing originates from reduced expression or phosphorylation
and subcellular localisation of proteins involved in the protective signalling cascades, …

… cardioprotective potential is also affected by age in the diabetic heart. Previously, it was
demonstrated that the young, diabetic heart is still amenable to IPC protection, but the threshold …

… underlying loss of endogenous cardioprotective responses. … age-associated molecular
changes underlying altered cardiac energetics, sensitivity to oxidative stress and cardioprotective …

… show that IP's cardioprotection is lost in aged mouse heart in vivo. In the aged compared
with … Several genes are differentially expressed in the aged myocardium (40), among them …

… cardioprotective agents in an aged myocardium. Interactions among the cardioprotective
agents outlined herein suggest that age‐… understood before cardioprotective interventions that …

… The loss of proteostasis is considered a major hallmark of ageing, the consequences of …
from accumulating within the cells, inducing loss of function and cytotoxicity. The efficiency of the …

… myocardial infarction is also protective in aged patients. … they excluded a correlation between
age-related higher mortality for … stenoses did not differ according to age group in 20% of …

… We aim to explore the role of Sirt 1 in the loss of the cardioprotective effect of IPC with age. …
with age during ischemia/reperfusion, our data suggest that the loss of the cardioprotective …