Abstract Introduction BRCA1-associated protein 1 (BAP1) is a gene situated on
chromosome 3p in a region that is deleted in more than 90% of renal cell carcinomas
(RCCs). In the present study, we studied BAP1 immunohistochemical expression in a large
series of conventional clear cell RCCs (ccRCCs) treated with radical nephrectomy; we
assessed the prognostic value of their expression in terms of patients׳ survival at long-term
follow-up. Materials and methods A total of 154 consecutive patients with ccRCC were …

BAP1 is a gene situated on chromosome 3p in a region that is deleted in over 90% of Renal
Cell Carcinomas (RCCs)(1, 2). In the present study we studied BAP1 immunohistochemical
expression in a large series of conventional clear cell RCCs (ccRCCs) treated with radical
nephrectomy and we assessed the prognostic value of their expression in terms of patients
survival at long-term follow-up. 154 consecutive patients with ccRCC were selected from a
prospective database and considered for the study purpose; all patients were treated with …