Self-amplifying RNA approach for protein replacement therapy

D Papukashvili, N Rcheulishvili, C Liu, Y Ji… - International journal of …, 2022 - mdpi.com
… conventional mRNA vaccine with multiple advantages, especially its low dosage [5], …
mRNA-4157, mRNA-5671, and mRNA-4359 designed by Moderna as personalized cancer vaccine (…

Delivery of synthetic mRNAs for tissue regeneration

H Steinle, J Weber, S Stoppelkamp… - Advanced drug delivery …, 2021 - Elsevier
… two synthetic mRNA-based vaccines, BNT162b2 and mRNA-1273, for therapeutic use after
… CLDN6 protein had to be administered three times a week with a total amount of ten doses of …

[图书][B] Trends in mRNA Vaccine Research

J Fischer, C Klein, WE Childers - 2024 - books.google.com
dose of vaccination in preventing symptomatic SARS-CoV-2 … To understand why it took
so long for mRNA vaccines to … -19 mRNA vaccines BNT162b2 and mRNA-1273, every …

[PDF][PDF] Adjunct Professor of Neurosurgery, University of Pennsylvania, Philadelphia USA

K Karikó - consejoculturalmundial.org
Had these scientists not persevered over decades to … vaccine platform to develop second
generation SARS-CoV-2 … $3,000 to greater than $10,000 per dose and are dosed as frequently …

Mesenchymal stem cells as a gene delivery tool: Promise, problems, and prospects

N Attia, M Mashal, G Puras, JL Pedraz - Pharmaceutics, 2021 - mdpi.com
… -19 vaccines, developed by Pfizer-BioNTech and Moderna, that received emergency use …
such as, timing, dosage, and administration route of transplanted MSCs. For hMSCs to be used …

Uridine-depleted hCFTR mRNA-delivery to restore hCFTR expression and function in vitro and in vivo

CC Dorhs - 2024 - tobias-lib.ub.uni-tuebingen.de
… 12 adult CF patients received either a single dose of MRT5005 or placebo. MRT5005
was administered in three different doses: 8, 16 and 24 mg. There were no treatment-emergent …

Development of antifibrotic therapy for stricturing Crohn's disease: lessons from randomized trials in other fibrotic diseases

SN Lin, R Mao, C Qian, D Bettenworth… - Physiological …, 2022 - journals.physiology.org
… were enrolled in this study and randomly assigned to receive … significantly lower in the
nintedanib group with the dose of … fibrosis scores in kidney transplant recipients managed with …

Regulation of hyaluronan biosynthesis: Expression in vitro and importance for tumor progression

A Jacobson - 2002 - diva-portal.org
… The brain endothelial cells used in this study produced low amounts of hyaluronan. The …
(Table 2, paper II). With regard to tumor vascularization, where Has2 tumors had significantly …

A chemical and pharmacological study of a commercial Andrographis paniculata extract and andrographolide, to determine their anti-inflammatory drug potential

MN Low - 2015 - search.proquest.com
… To my father in law Joe for extending our home so that our new daughter had her own room
and we could enjoy sleep. To my daughter Penelope, who has made e the last year much …

Immunostimulatory Properties of Nucleic Acid Nanoparticles

JR Halman - 2020 - search.proquest.com
… This dissertation aims to elucidate the link between structure and composition of nucleic
acid nanoparticles and their ability to produce an immune response in cells. Furthermore, the …