Lysozyme elicits pain during nerve injury by neuronal Toll-like receptor 4 activation and has therapeutic potential in neuropathic pain
The role of neuronal Toll-like receptor 4 (TLR4) in nerve injury is being pursued actively.
However, the endogenous activation of neuronal TLR4 during neuroinflammation, in
absence of the participation of glial TLR4, remains elusive. Here, we identified lysozyme as
an endogenous activator of neuronal TLR4 signaling during nerve injury. Upon nerve injury,
enhanced expression of lysozyme promoted neuronal hyperexcitability and neuropathic
pain. Injections of lysozyme in healthy rats increased their mechanical and thermal pain …
However, the endogenous activation of neuronal TLR4 during neuroinflammation, in
absence of the participation of glial TLR4, remains elusive. Here, we identified lysozyme as
an endogenous activator of neuronal TLR4 signaling during nerve injury. Upon nerve injury,
enhanced expression of lysozyme promoted neuronal hyperexcitability and neuropathic
pain. Injections of lysozyme in healthy rats increased their mechanical and thermal pain …
以上显示的是最相近的搜索结果。 查看全部搜索结果