MITF and PU. 1 recruit p38 MAPK and NFATc1 to target genes during osteoclast differentiation
Transcription factors NFATc1, PU. 1, and MITF collaborate to regulate specific genes in
response to colony-stimulating factor-1 (CSF-1) and receptor activator of NF-κB ligand
(RANKL) signaling during osteoclast differentiation. However, molecular details concerning
timing and mechanism of specific events remain ill-defined. In bone marrow-derived
precursors, CSF-1 alone promoted assembly of MITF-PU. 1 complexes at osteoclast target
gene promoters like cathepsin K and acid 5 phosphatase without increasing gene …
response to colony-stimulating factor-1 (CSF-1) and receptor activator of NF-κB ligand
(RANKL) signaling during osteoclast differentiation. However, molecular details concerning
timing and mechanism of specific events remain ill-defined. In bone marrow-derived
precursors, CSF-1 alone promoted assembly of MITF-PU. 1 complexes at osteoclast target
gene promoters like cathepsin K and acid 5 phosphatase without increasing gene …
以上显示的是最相近的搜索结果。 查看全部搜索结果