… antibiotics remains a major challenge for drug discovery. The present study explores use of
phenotypic … screening and genomic approach. Deployment of the semi-automated bacterial …

… Early drug discovery campaigns are traditionally categorized into target-based drug discovery
(TBDD) and phenotypic drug discovery … that interact with a known drug target. Thus, TBDD …

… antibiotics, therapies decline in efficacy and must be replaced, distinguishing antibiotics from
most other forms of drug development… , the phenotypic drug discovery approach focuses not …

… a pre-antibiotic era. Nevertheless, new emerging AI-based technologies have started to enter
the field of antibiotic and drug development, … the specific bacterial phenotypic fingerprints in …

… approach, accelerating drug discovery because of its fast pace, … to discover several
beta-lactamase inhibitors and antibiotic … , phenotypic drug discovery (PDD) is a valid alternative for …

… as known antibiotics, natural products, or past drug discovery … 'discovery void' and have
impaired antibiotic research in … million deaths attributed directly to antibiotic resistance annually…

… antibacterial drug discovery. (4) Finally, considering the growing need for novel antibiotics to
… resistance, we reasoned that antibacterial drug discovery could be an especially promising …

… 21 st century, the pace of antibiotic drug discovery clearly cannot keep up with the continuous
… Additionally, the prediction of antibiotic resistance phenotypes from genomic information …

… Many drugs, or their antecedents, were discovered through … For the past generation, this
phenotypic drug discovery approach … Nevertheless, modern phenotypic drug discovery, which …

… machine learning classifiers can accurately predict ciprofloxacin susceptibility without
exposure to it or any prior knowledge of resistance phenotype… microbiology and drug discovery, …