Macrocycles from pentafluoropyridine and tetrafluoropyrimidine
R Ranjbar-Karimi, G Sandford, DS Yufit… - Journal of Fluorine …, 2008 - Elsevier
R Ranjbar-Karimi, G Sandford, DS Yufit, JAK Howard
Journal of Fluorine Chemistry, 2008•Elsevier… We also extend this methodology to the incorporation of pyrimidine units by utilising
tetrafluoropyrimidine 7 as the starting material in macrocyclic synthesis for the first time. … In
summary, macrocycles may be synthesised by reaction of pentafluoropyridine and
tetrafluoropyrimidine by linking positions most reactive towards nucleophilic attack by various
diamine-bridging units. The range of macrocyclic structures with differing architectures that may
be accessed using this S N Ar ring-closing methodology is, therefore, expanded considerably. …
tetrafluoropyrimidine 7 as the starting material in macrocyclic synthesis for the first time. … In
summary, macrocycles may be synthesised by reaction of pentafluoropyridine and
tetrafluoropyrimidine by linking positions most reactive towards nucleophilic attack by various
diamine-bridging units. The range of macrocyclic structures with differing architectures that may
be accessed using this S N Ar ring-closing methodology is, therefore, expanded considerably. …
Macrocycles were synthesised by sequential nucleophilic aromatic substitution processes involving pentafluoropyridine and tetrafluoropyrimidine and various diamines as the structural components.
Elsevier
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