PPARγ is required for fat cell development and is the molecular target of antidiabetic
thiazolidinediones (TZDs), which exert insulin-sensitizing effects in adipose tissue, skeletal
muscle, and liver. Unexpectedly, we found that inactivation of PPARγ in macrophages
results in the development of significant glucose intolerance plus skeletal muscle and
hepatic insulin resistance in lean mice fed a normal diet. This phenotype was associated
with increased expression of inflammatory markers and impaired insulin signaling in …

Macrophage PPARγ is required for normal skeletal muscle and hepatic insulin sensitivity
and full antidiabetic effects of thiazolidinediones | CiNii Research … Macrophage PPARγ is
required for normal skeletal muscle and hepatic insulin sensitivity and full antidiabetic
effects of thiazolidinediones …