Macrophage migration inhibitory factor drives pathology in a mouse model of spondyloarthritis and is associated with human disease
Spondyloarthritis (SpA), a type 3 immunity-mediated inflammatory arthritis, is a systemic
rheumatic disease that primarily affects the joints, spine, gut, skin, and eyes. Macrophage
migration inhibitory factor (MIF) is a proinflammatory cytokine, yet MIF's pathological role in
SpA is unknown. Here, we observed that the expression of MIF and its receptor CD74 is
increased in blood and tissues of curdlan (β-glucan)–treated SKG mice, a mouse model of
SpA. We found that neutrophils substantially expanded and produced MIF in curdlan-treated …
rheumatic disease that primarily affects the joints, spine, gut, skin, and eyes. Macrophage
migration inhibitory factor (MIF) is a proinflammatory cytokine, yet MIF's pathological role in
SpA is unknown. Here, we observed that the expression of MIF and its receptor CD74 is
increased in blood and tissues of curdlan (β-glucan)–treated SKG mice, a mouse model of
SpA. We found that neutrophils substantially expanded and produced MIF in curdlan-treated …
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