Macrophage tolerance: CD47–SIRP-α–mediated signals matter
H Takizawa, MG Manz - Nature immunology, 2007 - nature.com
H Takizawa, MG Manz
Nature immunology, 2007•nature.com… On the basis of the mouse studies described above, SIRP-α-mediated macrophage
inhibition is determined by CD47 expression on the nonhematopoietic background 9 . If
CD47 protein is not polymorphic or otherwise differently expressed by donor and recipient
within one species, then the binding specificity of polymorphic SIRP-α to donor and
recipient CD47 will be same and thus should result in similar strength of signal transmission
to macrophages. In contrast, donor cells might receive a signal of altered intensity through …
inhibition is determined by CD47 expression on the nonhematopoietic background 9 . If
CD47 protein is not polymorphic or otherwise differently expressed by donor and recipient
within one species, then the binding specificity of polymorphic SIRP-α to donor and
recipient CD47 will be same and thus should result in similar strength of signal transmission
to macrophages. In contrast, donor cells might receive a signal of altered intensity through …
Inhibition of phagocyte activity depends on the ligation of SIRP-α by CD47. New findings show that Sirpa polymorphisms influence the engraftment and tolerance of xenogeneic transplants in NOD-SCID mice.
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