Macrophage-derived IL1β and TNFα regulate arginine metabolism in neuroblastoma
Neuroblastoma is the most common childhood solid tumor, yet the prognosis for high-risk
disease remains poor. We demonstrate here that arginase 2 (ARG2) drives neuroblastoma
cell proliferation via regulation of arginine metabolism. Targeting arginine metabolism, either
by blocking cationic amino acid transporter 1 (CAT-1)–dependent arginine uptake in vitro or
therapeutic depletion of arginine by pegylated recombinant arginase BCT-100, significantly
delayed tumor development and prolonged murine survival. Tumor cells polarized infiltrating …
disease remains poor. We demonstrate here that arginase 2 (ARG2) drives neuroblastoma
cell proliferation via regulation of arginine metabolism. Targeting arginine metabolism, either
by blocking cationic amino acid transporter 1 (CAT-1)–dependent arginine uptake in vitro or
therapeutic depletion of arginine by pegylated recombinant arginase BCT-100, significantly
delayed tumor development and prolonged murine survival. Tumor cells polarized infiltrating …
Macrophage-derived IL-1? and TNF-? regulate arginine metabolism in neuroblastoma
SA Burchill, DS Ziegler, HC Etchevers… - Cancer … - nottingham-repository.worktribe.com
© 2018 American Association for Cancer Research. Neuroblastoma is the most common
childhood solid tumor, yet the prognosis for high-risk disease remains poor. We demonstrate
here that arginase 2 (ARG2) drives neuroblastoma cell proliferation via regulation of
arginine metabolism. Targeting arginine metabolism, either by blocking cationic amino acid
transporter 1 (CAT-1)-dependent arginine uptake in vitro or therapeutic depletion of arginine
by pegylated recombinant arginase BCT-100, significantly delayed tumor development and …
childhood solid tumor, yet the prognosis for high-risk disease remains poor. We demonstrate
here that arginase 2 (ARG2) drives neuroblastoma cell proliferation via regulation of
arginine metabolism. Targeting arginine metabolism, either by blocking cationic amino acid
transporter 1 (CAT-1)-dependent arginine uptake in vitro or therapeutic depletion of arginine
by pegylated recombinant arginase BCT-100, significantly delayed tumor development and …
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