Mammalian thioredoxin reductase is irreversibly inhibited by dinitrohalobenzenes by alkylation of both the redox active selenocysteine and its neighboring cysteine …
J Nordberg, L Zhong, A Holmgren, ESJ Arnér - Journal of Biological …, 1998 - ASBMB
The immunostimulatory dinitrohalobenzene compound 1-chloro-2, 4-dinitrobenzene
(DNCB) irreversibly inhibits mammalian thioredoxin reductase (TrxR) in the presence of
NADPH, inducing an NADPH oxidase activity in the modified enzyme (Arnér, ESJ,
Björnstedt, M., and Holmgren, A.(1995) J. Biol. Chem. 270, 3479–3482). Here we have
further analyzed the reactivity with the enzyme of DNCB and analogues with varying
immunomodulatory properties. We have also identified the reactive residues in bovine …
(DNCB) irreversibly inhibits mammalian thioredoxin reductase (TrxR) in the presence of
NADPH, inducing an NADPH oxidase activity in the modified enzyme (Arnér, ESJ,
Björnstedt, M., and Holmgren, A.(1995) J. Biol. Chem. 270, 3479–3482). Here we have
further analyzed the reactivity with the enzyme of DNCB and analogues with varying
immunomodulatory properties. We have also identified the reactive residues in bovine …
以上显示的是最相近的搜索结果。 查看全部搜索结果