incomplete closure of the vertebral column and malformation of the embryonic neural tube.
This condition is associated with a prenatal folate deficiency and may occur more frequently
in genetically susceptible individuals or mothers exposed to hyperthermia during pregnancy.
1, 2 Although the estimated occurrence is 1 per 1000 births, the rate of spina bifida and
anencephaly in the United States has been decreasing since the Federal Drug …