Several studies have confirmed the relationship between marital quality and well-being. In this chapter we review studies that examine the relationship between marital satisfaction and well-being, particularly focusing on the moderating role of gender, marital duration and social support, and the mediating role of spousal support. As the impact of gender and social support depends on the cultural context, we briefly present findings from a preliminary study conducted with 95 married couples from Greek urban and rural areas. The findings confirmed the negative relationship between marital satisfaction and depressive symptoms. Partner’s perceived marital satisfaction and spousal support, gender and social support from family and friends moderated the relationship between marital satisfaction and depressive symptoms. The area of residence moderated the relationship between social support from others and depressive symptoms. The results regarding the moderating role of gender and social support are inconsistent with the international literature and highlight the importance of taking into consideration the interpersonal and social context of well-being.