Marked genetic differences between BRAF and NRAS mutated primary melanomas as revealed by array comparative genomic hybridization
V Lazar, S Ecsedi, L Vízkeleti, Z Rakosy… - Melanoma …, 2012 - journals.lww.com
Somatic mutations of BRAF and NRAS oncogenes are thought to be among the first steps in
melanoma initiation, but these mutations alone are insufficient to cause tumor progression.
Our group studied the distinct genomic imbalances of primary melanomas harboring
different BRAF or NRAS genotypes. We also aimed to highlight regions of change commonly
seen together in different melanoma subgroups. Array comparative genomic hybridization
was performed to assess copy number changes in 47 primary melanomas. BRAF and NRAS …
melanoma initiation, but these mutations alone are insufficient to cause tumor progression.
Our group studied the distinct genomic imbalances of primary melanomas harboring
different BRAF or NRAS genotypes. We also aimed to highlight regions of change commonly
seen together in different melanoma subgroups. Array comparative genomic hybridization
was performed to assess copy number changes in 47 primary melanomas. BRAF and NRAS …