Maternal antiviral immunoglobulin accumulates in neural tissue of neonates to prevent HSV neurological disease

Y Jiang, CD Patel, R Manivanh, B North, IM Backes… - MBio, 2017 - Am Soc Microbiol
… naive and HSV-infected neural tissue of mice and humans for the presence of antibody.
We … We have yet to address whether maternal IgG can effectively combat neonatal HSV-2. …

[PDF][PDF] Maternal antiviral immunoglobulin accumulates in neural tissue of neonates to prevent HSV neurological disease. mBio 8: e00678-17

Y Jiang, CD Patel, R Manivanh, B North, IM Backes… - 2017 - geiselmed.dartmouth.edu
… naive and HSV-infected neural tissue of mice and humans for the presence of antibody.
We … We have yet to address whether maternal IgG can effectively combat neonatal HSV-2. …

Preventing neonatal herpes infections through maternal immunization

J Yike, D Leib - Future Virology, 2017 - Taylor & Francis
maternal antibody production during pregnancy. In a recent study by our group, we found that
antiviral maternal … In summary, the efficacy of maternal vaccines against neonatal HSV has …

Harnessing maternal humoral immunity to prevent neonatal herpes neurological sequela

CD Patel - 2020 - search.proquest.com
… Latency is refractory to antiviral treatment, which targets … The concept of maternal antibody
protection of HSV is the focus of … that maternal antibody can access fetal neural tissue through …

Maternal immunization confers protection against neonatal herpes simplex mortality and behavioral morbidity

CD Patel, IM Backes, SA Taylor, Y Jiang… - Science translational …, 2019 - science.org
… transfer of HSV-specific IgG is protective to neonates, we … aggressive antiviral treatment
(58). In this study, we found that … Accumulating evidence suggests that prenatal and postnatal …

[HTML][HTML] Pregnancy and viral infections: Mechanisms of fetal damage, diagnosis and prevention of neonatal adverse outcomes from cytomegalovirus to SARS-CoV-2 …

C Auriti, DU De Rose, A Santisi, L Martini… - … et Biophysica Acta (BBA …, 2021 - Elsevier
… profile of antivirals for the treatment of neonatal consequences of … neonates than primary
HSV genital lesions; c) maternal … weeks of gestation with an immunoglobulin G-based assay …

Management of neonatal herpes simplex virus infection

AM Kesson - Paediatric drugs, 2001 - Springer
maternal HSV antibody at birth, whereas those infants born … [16] Aciclovir also accumulates
in the breast milk.[20] There is … In addition to specific antiviral therapy, a neonate with HSV

Monoclonal antibody therapy of herpes simplex virus: An opportunity to decrease congenital and perinatal infections

IM Backes, DA Leib, ME Ackerman - Frontiers in Immunology, 2022 - frontiersin.org
… Despite treatment with antiviral drugs, neonatal HSV (nHSV) infections … of monoclonal
antibody therapies to treat or prevent HSV infection and … Maternal and neonatal HSV infections …

Herpes simplex virus infections in neonates and early childhood

DW Kimberlin - Seminars in pediatric infectious diseases, 2005 - Elsevier
… serodiscordant relationship through antiviral suppression of … of HSV from mother to neonate
are type of maternal infection … of preexisting antibody in preventing neonatal HSV disease. …

Maternally transferred mAbs protect neonatal mice from HSV-induced mortality and morbidity

IM Backes, BK Byrd, MD Slein, CD Patel… - Journal of Experimental …, 2022 - rupress.org
… morbidity despite antiviral drug therapy. Maternally transferred … Together our work demonstrates
that maternal or direct … Pregnant dams were administered either CH42 or control IgG ∼…