Maternal high-cholesterol diet negatively programs offspring bone development and downregulates hedgehog signaling in osteoblasts
Cholesterol is one of the essential intrauterine factors required for fetal growth and
development. Maternal high cholesterol levels are known to be detrimental for offspring
health. However, its long-term effect on offspring skeletal development remains to be
elucidated. We performed our studies in two strains of mice (C57BL6/J and Swiss Albino)
and human subjects (65 mother–female newborn dyads) to understand the regulation of
offspring skeletal growth by maternal high cholesterol. We found that mice offspring from …
development. Maternal high cholesterol levels are known to be detrimental for offspring
health. However, its long-term effect on offspring skeletal development remains to be
elucidated. We performed our studies in two strains of mice (C57BL6/J and Swiss Albino)
and human subjects (65 mother–female newborn dyads) to understand the regulation of
offspring skeletal growth by maternal high cholesterol. We found that mice offspring from …
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