Maternal overnutrition before and during pregnancy induces DNA damage in male offspring: A rabbit model
AM Salazar, M Sordo, E Navarrete-Monroy… - … /Genetic Toxicology and …, 2021 - Elsevier
Using a rabbit model, we investigated whether maternal intake of a high-fat and high-
carbohydrate diet (HFCD) before and during pregnancy induces an increase in micronuclei
frequency and oxidative stress in offspring during adulthood. Female rabbits received a
standard diet (SD) or HFCD for two months before mating and during gestation. The
offspring from both groups were nursed by foster mothers fed SD until postnatal day 35. After
weaning, all the animals received SD until postnatal day 440. At postnatal day 370, the …
carbohydrate diet (HFCD) before and during pregnancy induces an increase in micronuclei
frequency and oxidative stress in offspring during adulthood. Female rabbits received a
standard diet (SD) or HFCD for two months before mating and during gestation. The
offspring from both groups were nursed by foster mothers fed SD until postnatal day 35. After
weaning, all the animals received SD until postnatal day 440. At postnatal day 370, the …