Maurotoxin versus Pi1/HsTx1 scorpion toxins: Toward new insights in the understanding of their distinct disulfide bridge patterns
Maurotoxin (MTX) is a scorpion toxin acting on several K+ channel subtypes. It is a 34-
residue peptide cross-linked by four disulfide bridges that are in an" uncommon"
arrangement of the type C1-C5, C2-C6, C3-C4, and C7-C8 (versus C1-C5, C2-C6, C3-C7,
and C4-C8 for Pi1 or HsTx1, two MTX-related scorpion toxins). We report here that a single
mutation in MTX, in either position 15 or 33, resulted in a shift from the MTX toward the
Pi1/HsTx1 disulfide bridge pattern. This shift is accompanied by structural and …
residue peptide cross-linked by four disulfide bridges that are in an" uncommon"
arrangement of the type C1-C5, C2-C6, C3-C4, and C7-C8 (versus C1-C5, C2-C6, C3-C7,
and C4-C8 for Pi1 or HsTx1, two MTX-related scorpion toxins). We report here that a single
mutation in MTX, in either position 15 or 33, resulted in a shift from the MTX toward the
Pi1/HsTx1 disulfide bridge pattern. This shift is accompanied by structural and …
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