Heterosis, heterobeltiosis and inbreeding depression for grain yield and its components were studied through 6 crosses in F1 and F2 generations. These crosses were resulted from half diallel mating design between 4 different parents in 2014/2015. In 2017/2018 season, an experiment was conducted in randomized complete block design with three replications at Faculty of Agriculture, Cairo University, Giza, Egypt to evaluate the 16 genotypes (4 parental lines and their 6 crosses in F1 and 6 crosses in F2). Moreover, simple phenotypic correlation and path analysis were performed to study the nature of associations between grain yield and its components. The results showed that, for grain yield plant-1, the cross combination (P2× P3) depicted the highest significant and positive heterosis (88.12%) and heterobeltiosis (81.9%) followed by cross combination (P1 xP2) which exhibited a high positive significant heterosis (83.43%) and high positive significant heterobeltiosis (60.35%). Concerning inbreeding depression, highly significant and positive values of inbreeding depression were detected for total dry matter, spike dry matter, grain yield plant-1 and 1000-kernels weight for all crosses. On the other hand, significant and negative values of inbreeding depression were detected in plant height, No. of spikes plant-1, spike length, harvest index and No. of kernels spike-1. Respect to the correlation analysis. The results showed that, highly significant and positive correlation was observed between grain yield plant-1 and each of No. of spikes plant-1 (r= 0.64**), biological yield (r= 0.94**), spike dry matter (r= 0.98**) and 1000-kernels weight (r= 0.76**). Concerning path-analysis technique, the spike number plant-1 exhibited the highest direct effect value (0.61) towards grain yield plant-1 followed by number of kernels spike-1 which exhibited a high degree of direct effect (0.547). The greatest indirect effect on grain yield plant-1 was achieved by total dry matter via number of spikes plant-1. It could be concluded that, plant height, number of spikes plant-1, spike length, No. of kernels spike-1 and 1000-kernels weight are major components of wheat yield and could be used as selection criteria in the breeding programs.