Mechanism and manipulation of DNA: RNA hybrid G-quadruplex formation in transcription of G-rich DNA
We recently reported that a DNA: RNA hybrid G-quadruplex (HQ) forms during transcription
of DNA that bears two or more tandem guanine tracts (G-tract) on the nontemplate strand.
Putative HQ-forming sequences are enriched in the nearby 1000 nt region right downstream
of transcription start sites in the nontemplate strand of warm-blooded animals, and HQ
regulates transcription under both in vitro and in vivo conditions. Therefore, knowledge of
the mechanism of HQ formation is important for understanding the biological function of HQ …
of DNA that bears two or more tandem guanine tracts (G-tract) on the nontemplate strand.
Putative HQ-forming sequences are enriched in the nearby 1000 nt region right downstream
of transcription start sites in the nontemplate strand of warm-blooded animals, and HQ
regulates transcription under both in vitro and in vivo conditions. Therefore, knowledge of
the mechanism of HQ formation is important for understanding the biological function of HQ …
[引用][C] Mechanism and Manipulation of DNA: RNA Hybrid G-Quadruplex Formation in Transcription of G-Rich DNA
张佳宇， 郑克威， 肖姗， 郝玉华， 谭铮 - 2014 - 159.226.67.71
We recently reported that a DNA: RNA hybrid G-quadruplex (HQ) forms during transcription
of DNA that bears two or more tandem guanine tracts (G-tract) on the nontemplate strand.
Putative HQ-forming sequences are enriched in the nearby 1000 nt region right downstream
of transcription start sites in the nontemplate strand of warm-blooded animals, and HQ
regulates transcription under both in vitro and in vivo conditions. Therefore, knowledge of
the mechanism of HQ formation is important for understanding the biological function of HQ …
of DNA that bears two or more tandem guanine tracts (G-tract) on the nontemplate strand.
Putative HQ-forming sequences are enriched in the nearby 1000 nt region right downstream
of transcription start sites in the nontemplate strand of warm-blooded animals, and HQ
regulates transcription under both in vitro and in vivo conditions. Therefore, knowledge of
the mechanism of HQ formation is important for understanding the biological function of HQ …
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