… nongenotoxic peroxisome proliferators results in a marked increase in the number and size
of peroxisomes … In addition, long-term administration of peroxisome proliferators results in …

… nongenotoxic peroxisome proliferators is not well understood. To determine whether
nongenotoxic … , we evaluated the effect of the prototypical peroxisome proliferator Wy-14,643 on …

… Like mitochondria peroxisomes contain a complete fatty acid P-oxidation cycle [2,4]. This
paper will focus on mechanisms of peroxisome proliferator-induced …

… Peroxisome proliferators are nongenotoxic rodent carcinogens … ; however, their precise
mechanism of action is not well understood… In animal cells both mitochondria and peroxisome are …

… Of considerable significance is the observation that these agents also induce hepatocellular
carcinomas in rats and mice despite their non-genotoxic nature. The postulated link …

… The purpose of this review is to briefly consider the various mechanisms of peroxisome
proliferator-… show no detectable mutagenic activity, and are therefore classified as non-genotoxic …

… Peroxisome proliferators are termed nongenotoxic carcinogens since they fail to cause
DNA damage directly when tested using a number of genotoxic assays, for example, the Ames …

… Peroxisome proliferators are a structurally diverse group of non-genotoxic chemicals that …
which activates flavin-containing oxidases in mitochondria and peroxisomes, resulting in H 2 O …

… The oxidative stress hypothesis was proposed by Reddy to explain how these non-genotoxic
peroxisome proliferators may produce rodent liver cancer 111. It is proposed that hydrogen …

… A more definitive role for cell proliferation in … Compared to the foci induced by other genotoxic
or nongenotoxic … with foci and tumors induced by other nongenotoxic carcinogens or DNA-…