… the mechanism(s) of paclitaxel activity in KS by utilizing a model of experimental KS that is
… By using this model, we found that paclitaxel promotes regression of KS lesions in vivo. By …

… We show that the mechanism of anti-tumor action of paclitaxel in KS is accompanied by …
The major mechanism of paclitaxel antitumor activity in this model appears to be induction …

… With continued disease stability, he was adjusted to every 4-week paclitaxel therapy for …
Paclitaxel has shown both in-vitro and in-vivo evidence of activity against Kaposi's sarcoma due …

… Kaposi’s sarcoma (KS) is an angioproliferative disease characterized by proliferation of
spindle-shaped cells predominantly of endothelial cell origin, neoangiogenesis, inflammatory …

… The mechanism of paclitaxel activity in KS has been investigated using other models of
experimental KS induced by the inoculation of KS-derived spindle cells into nude mice and …

… mechanism of action and antitumor activity of this drug, combined with its profound antiangiogenic
activity, provides strong rationales for the use of paclitaxel in … Paclitaxel has previously …

… The major mechanism of cytotoxicity of taxanes including paclitaxel is attributed to binding …
Published reports and personal experience confirm that paclitaxel has marked activity against …

… ,37 Also, several recent observations have provided another mechanism that might explain
the high activity of paclitaxel in KS. KS-derived spindle cells have been found to express a …

… effects which are exerted by several mechanisms. In fact, it … The efficacy of paclitaxel with
low toxicity has also been … Like IFN, thalidomide shows a range of activities that could influence …

… Paclitaxel has proved to be highly effective in the treatment of severe AIDS‐related Kaposi
sarcoma (KS), for which it is … It also has antiangiogenic activity because it alters cytoskeletal …