Meibomian gland dysfunction is suppressed via selective inhibition of immune responses by topical LFA-1/ICAM antagonism with lifitegrast in the allergic eye disease …
Purpose The etiology of meibomian gland dysfunction (MGD) is incompletely understood,
despite being a common ophthalmic condition and an area of unmet medical need. It is
characterized by an insufficiency in glandular provision of specialized lipids (meibum) to the
tear film and is a major cause of dry eye. Work in the allergic eye disease (AED) mouse
model has revealed an immunopathogenic role in MGD causation, now raising interest in
the applicability of immunomodulatory therapies. As such, we herein ask whether inhibition …
despite being a common ophthalmic condition and an area of unmet medical need. It is
characterized by an insufficiency in glandular provision of specialized lipids (meibum) to the
tear film and is a major cause of dry eye. Work in the allergic eye disease (AED) mouse
model has revealed an immunopathogenic role in MGD causation, now raising interest in
the applicability of immunomodulatory therapies. As such, we herein ask whether inhibition …
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