Meiotic recombination events are distributed unevenly throughout eukaryotic genomes. This
inhomogeneity leads to distortions of genetic maps that can hinder the ability of geneticists
to identify genes by map-based techniques. Various lines of evidence, particularly from
studies of yeast, indicate that the distribution of recombination events might reflect, at least in
part, global features of chromosome structure, such as the distribution of modified
nucleosomes.