Melastoma malabathricum L. has been used as a traditional medicine in different parts of the world. The aim of this review is to summarize and critically analyze the literature on traditional uses, phytochemistry and bioactivities of M. malabathricum. The literature was retrieved from scientific databases. The leaves, flowers, stem and roots are being used for wound healing, treating stomachache, measles, low sperm count, jaundice, pain, leucorrhoea, diarrhea, dysentery, tooth decay, and fever. It contains 71 phytochemicals; flavonoids, terpenoids, tannins, sterols, amides, glycolipids and fatty acids. Extracts demonstrated antimicrobial, gastroprotective, hepatoprotective, anti-inflammatory, antioxidant, cytotoxic, anticancer, wound healing, antinociceptive, antihyperlipidemic, anti-infertile, antiarthritic and antidiabetic activities. This review provides insights on traditional uses, phytochemical constituents, and bioactivities of M. malabathricum L. Few papers in the literature were found to be lacking in scientific vigor. Further studies should be carried out on safe use of M. malabathricum L. and mechanisms underlying its bioactivities.