Membrane targeting of inhibitory Smads through palmitoylation controls TGF-β/BMP signaling
TGF-β/BMP (bone morphogenetic protein) signaling pathways play conserved roles in
controlling embryonic development, tissue homeostasis, and stem cell regulation. Inhibitory
Smads (I-Smads) have been shown to negatively regulate TGF-β/BMP signaling by primarily
targeting the type I receptors for ubiquitination and turnover. However, little is known about
how I-Smads access the membrane to execute their functions. Here we show that Dad, the
Drosophila I-Smad, associates with the cellular membrane via palmitoylation, thereby …
controlling embryonic development, tissue homeostasis, and stem cell regulation. Inhibitory
Smads (I-Smads) have been shown to negatively regulate TGF-β/BMP signaling by primarily
targeting the type I receptors for ubiquitination and turnover. However, little is known about
how I-Smads access the membrane to execute their functions. Here we show that Dad, the
Drosophila I-Smad, associates with the cellular membrane via palmitoylation, thereby …
[PDF][PDF] Membrane targeting of inhibitory Smads through palmitoylation controls TGF-β/BMP signaling
李文卿， 李玮妮， 邹丽辉， 计山明， 李超逸， 张国强… - 2017 - library.ioz.ac.cn
TGF-β/BMP (bone morphogenetic protein) signaling pathways play conserved roles in
controlling embryonic development, tissue homeostasis, and stem cell regulation. Inhibitory
Smads (I-Smads) have been shown to negatively regulate TGF-β/BMP signaling by primarily
targeting the type I receptors for ubiquitination and turnover. However, little is known about
how I-Smads access the membrane to execute their functions. Here we show that Dad, the
Drosophila I-Smad, associates with the cellular membrane via palmitoylation, thereby …
controlling embryonic development, tissue homeostasis, and stem cell regulation. Inhibitory
Smads (I-Smads) have been shown to negatively regulate TGF-β/BMP signaling by primarily
targeting the type I receptors for ubiquitination and turnover. However, little is known about
how I-Smads access the membrane to execute their functions. Here we show that Dad, the
Drosophila I-Smad, associates with the cellular membrane via palmitoylation, thereby …
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