In course of past few years, pharmaceutical industries have huge contribution in the economic development of the country, but concurrently the pharmaceutical pollutants can also be responsible for severe hazards to the environment. Traditional methods of wastewater treatment cannot erase these pollutants from the water due to their hostile behavior. The advent of the pharmaceutical pollutants leads a demand for assessment and depiction of the wastewater discharged from the pharmaceutical industry as per the norms recommended by the official agency (Pollution Control Board). Vast number of treatment strategies are adapted by the pharmaceutical industries to reuse wastewater and regulate environmental pollution. In this chapter, we mainly focus on the finest membrane based methodologies to abolish the pharmaceutical compounds. At present, no individual technology has the potential to expel out the pharmaceutical pollutants from wastewater. Merging of traditional methods with membrane reactors leads to the best hybrid wastewater treatment technology.