Memory effects and Lévy walk dynamics in intracellular transport of cargoes
We demonstrate the phenomenon of cumulative inertia in intracellular transport involving
multiple motor proteins in human epithelial cells by measuring the empirical survival
probability of cargoes on the microtubule and their detachment rates. We found the longer a
cargo moves along a microtubule, the less likely it detaches from it. As a result, the
movement of cargoes is non-Markovian and involves a memory. We observe memory effects
on the scale of up to 2 s. We provide a theoretical link between the measured detachment …
multiple motor proteins in human epithelial cells by measuring the empirical survival
probability of cargoes on the microtubule and their detachment rates. We found the longer a
cargo moves along a microtubule, the less likely it detaches from it. As a result, the
movement of cargoes is non-Markovian and involves a memory. We observe memory effects
on the scale of up to 2 s. We provide a theoretical link between the measured detachment …
We demonstrate the phenomenon of cumulative inertia in intracellular transport involving multiple motor proteins in human epithelial cells by measuring the empirical survival probability of cargoes on the microtubule and their detachment rates. We found the longer a cargo moves along a microtubule, the less likely it detaches from it. As a result, the movement of cargoes is non-Markovian and involves a memory. We observe memory effects on the scale of up to 2 s. We provide a theoretical link between the measured detachment rate and the superdiffusive Lévy-walk-like cargo movement.
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