Metabolic switches and adaptations deduced from the proteomes of Streptomyces coelicolor wild type and phoP mutant grown in batch culture
Bacteria in the genus Streptomyces are soil-dwelling oligotrophs and important producers of
secondary metabolites. Previously, we showed that global messenger RNA expression was
subject to a series of metabolic and regulatory switches during the lifetime of a fermentor
batch culture of Streptomyces coelicolor M145. Here we analyze the proteome from eight
time points from the same fermentor culture and, because phosphate availability is an
important regulator of secondary metabolite production, compare this to the proteome of a …
secondary metabolites. Previously, we showed that global messenger RNA expression was
subject to a series of metabolic and regulatory switches during the lifetime of a fermentor
batch culture of Streptomyces coelicolor M145. Here we analyze the proteome from eight
time points from the same fermentor culture and, because phosphate availability is an
important regulator of secondary metabolite production, compare this to the proteome of a …
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