Two endophytic fungi LA (1) and LC (2) were isolated from the leaves of a Nigerian plant Euphorbia hirta. The fungi were subjected to solid state fermentation on rice medium and metabolites were extracted using ethyl acetate. The fungal crude extracts were screened for antimicrobial and antioxidant activities. The bioactive compounds of the extracts were detected using HPLC-DAD analysis. The fungal extracts showed both antibacterial and antifungal activities, but exhibited poor antioxidant activity. The HPLCDAD analysis of the extracts revealed the presence of citreoisocoumarinol and cladosporin in LA (1), and acropyrone in LC (2) as the major components of the extracts. Results of this study suggest that endophytic fungi associated with Nigerian plants could be a promising source of novel bioactive compounds with pharmaceutical and industrial importance.