Metformin depresses overactivated Notch1/Hes1 signaling in colorectal cancer patients with type 2 diabetes mellitus
B Yang, CZ Huang, T Yu, SN Zhou, Q Liu… - Anti-Cancer …, 2017 - journals.lww.com
The function of metformin in colorectal cancer (CRC) patients with diabetes mellitus (DM)
remains a controversial topic because studies are increasingly focusing on epidemiologic
features. We examined Notch1/Hes1 signaling in CRC with DM (DM-CRC) and investigated
alterations in signaling caused by metformin treatment. For this purpose, information on
pathological characteristics was collected from each patient. The proliferation of epithelium
labeled with proliferating cell nuclear antigen and the differentiation of goblet cells were …
remains a controversial topic because studies are increasingly focusing on epidemiologic
features. We examined Notch1/Hes1 signaling in CRC with DM (DM-CRC) and investigated
alterations in signaling caused by metformin treatment. For this purpose, information on
pathological characteristics was collected from each patient. The proliferation of epithelium
labeled with proliferating cell nuclear antigen and the differentiation of goblet cells were …
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