A small diameter flexible electrode designed for subcutaneous in vivo amperometric
monitoring of glucose is described. The electrode is designed to allow “one-point” in vivo
calibration, ie, to have zero output current at zero glucose concentration, even in the
presence of other electroreactive species of serum or blood. The electrode is preferably
three or four-layered, with the layers serially deposited within a recess upon the tip of a
polyamide insulated gold wire. A first glucose concentration-to-current transducing layer is …