Methods for determining key components in a mathematical model for tumor–immune dynamics in multiple myeloma
J Gallaher, K Larripa, M Renardy, B Shtylla… - Journal of theoretical …, 2018 - Elsevier
In this work, we analyze a mathematical model we introduced previously for the dynamics of
multiple myeloma and the immune system. We focus on four main aspects:(1) obtaining and
justifying ranges and values for all parameters in the model;(2) determining a subset of
parameters to which the model is most sensitive;(3) determining which parameters in this
subset can be uniquely estimated given certain types of data; and (4) exploring the model
numerically. Using global sensitivity analysis techniques, we found that the model is most …
multiple myeloma and the immune system. We focus on four main aspects:(1) obtaining and
justifying ranges and values for all parameters in the model;(2) determining a subset of
parameters to which the model is most sensitive;(3) determining which parameters in this
subset can be uniquely estimated given certain types of data; and (4) exploring the model
numerically. Using global sensitivity analysis techniques, we found that the model is most …
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