Methylene blue attenuates renal ischemia–reperfusion injury in rats
F Sarac, H Kilincaslan, E Kilic, M Koldas… - Journal of Pediatric …, 2015 - Elsevier
Background and purpose In our study, we investigated the effects of methylene blue (MB) on
histopathological changes in renal ischemia/reperfusion (I/R) injury rat model. Material and
methods Twenty-one Sprague–Dawley male rats were divided equally into three groups.
Group 1 (control) was administered intraperitoneal saline solution. In Groups 2 (untreated
group) and 3 (MB treatment), the renal arteries were clamped, and ischemia (for 1 hour) and
then reperfusion (for 4 hours) were applied. Thirty minutes before ischemia, the untreated …
histopathological changes in renal ischemia/reperfusion (I/R) injury rat model. Material and
methods Twenty-one Sprague–Dawley male rats were divided equally into three groups.
Group 1 (control) was administered intraperitoneal saline solution. In Groups 2 (untreated
group) and 3 (MB treatment), the renal arteries were clamped, and ischemia (for 1 hour) and
then reperfusion (for 4 hours) were applied. Thirty minutes before ischemia, the untreated …
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