Mex67p mediates nuclear export of a variety of RNA polymerase II transcripts
Mex67p is essential for nuclear poly (A)+ RNA export in yeast, but which specific transcripts
are transported by Mex67p is not known. We observed that thermosensitive mex67-5 cells
do not produce a heat shock response at 37° C but will induce heat shock proteins (Hsp)(eg
Hsp104p and Hsp70p) when shifted back from the restrictive to permissive temperature (30°
C). This memory of a previous heat stress in mex67-5 cells could be explained ifHSP
mRNAs accumulated inside the nucleus during heat shock and were exported and …
are transported by Mex67p is not known. We observed that thermosensitive mex67-5 cells
do not produce a heat shock response at 37° C but will induce heat shock proteins (Hsp)(eg
Hsp104p and Hsp70p) when shifted back from the restrictive to permissive temperature (30°
C). This memory of a previous heat stress in mex67-5 cells could be explained ifHSP
mRNAs accumulated inside the nucleus during heat shock and were exported and …
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