[HTML][HTML] MiR-139-5p is associated with inflammatory regulation through c-FOS suppression, and contributes to the progression of primary biliary cholangitis
T Katsumi, M Ninomiya, T Nishina, K Mizuno… - Laboratory …, 2016 - Elsevier
Primary biliary cholangitis (PBC) is a chronic cholestatic liver disease characterized
pathologically by destruction of intrahepatic bile ducts. PBC is largely classified into three
subtypes based on clinical course:(i) gradually progressive,(ii) portal hypertension, and (iii)
hepatic failure. Previous studies have indicated that serum levels of the pro-inflammatory
cytokine TNF-α, is elevated in PBC patients with fibrosis. Although the severity of cholangitis
might also be related to the PBC subtype, its etiology has been unclear. Several studies …
pathologically by destruction of intrahepatic bile ducts. PBC is largely classified into three
subtypes based on clinical course:(i) gradually progressive,(ii) portal hypertension, and (iii)
hepatic failure. Previous studies have indicated that serum levels of the pro-inflammatory
cytokine TNF-α, is elevated in PBC patients with fibrosis. Although the severity of cholangitis
might also be related to the PBC subtype, its etiology has been unclear. Several studies …
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