MicroRNA‐34a‐5p promotes joint destruction during osteoarthritis
H Endisha, P Datta, A Sharma… - Arthritis & …, 2021 - Wiley Online Library
Objective MicroRNA‐34a‐5p (miR‐34a‐5p) expression is elevated in the synovial fluid of
patients with late‐stage knee osteoarthritis (OA); however, its exact role and therapeutic
potential in OA remain to be fully elucidated. This study was undertaken to examine the role
of miR‐34a‐5p in OA pathogenesis. Methods Expression of miR‐34a‐5p was determined in
joint tissues and human plasma (n= 71). Experiments using miR‐34a‐5p mimic or antisense
oligonucleotide (ASO) treatment were performed in human OA chondrocytes, fibroblast‐like …
patients with late‐stage knee osteoarthritis (OA); however, its exact role and therapeutic
potential in OA remain to be fully elucidated. This study was undertaken to examine the role
of miR‐34a‐5p in OA pathogenesis. Methods Expression of miR‐34a‐5p was determined in
joint tissues and human plasma (n= 71). Experiments using miR‐34a‐5p mimic or antisense
oligonucleotide (ASO) treatment were performed in human OA chondrocytes, fibroblast‐like …
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