[HTML][HTML] MicroRNA-497 impairs the growth of chemoresistant neuroblastoma cells by targeting cell cycle, survival and vascular permeability genes
A Soriano, L París-Coderch, L Jubierre, A Martínez… - Oncotarget, 2016 - ncbi.nlm.nih.gov
Despite multimodal therapies, a high percentage of high-risk neuroblastoma (NB) become
refractory to current treatments, most of which interfere with cell cycle and DNA synthesis or
function, activating the DNA damage response (DDR). In cancer, this process is frequently
altered by deregulated expression or function of several genes which contribute to multidrug
resistance (MDR). MicroRNAs are outstanding candidates for therapy since a single
microRNA can modulate the expression of multiple genes of the same or different pathways …
refractory to current treatments, most of which interfere with cell cycle and DNA synthesis or
function, activating the DNA damage response (DDR). In cancer, this process is frequently
altered by deregulated expression or function of several genes which contribute to multidrug
resistance (MDR). MicroRNAs are outstanding candidates for therapy since a single
microRNA can modulate the expression of multiple genes of the same or different pathways …
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